Reactive species
Human;Rat;Mouse;
Immunogen
Synthesized peptide derived from human PCDAD AA range: 477-527
Specificity
This antibody detects endogenous levels of PCDAD at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.215% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
Other name
Protocadherin alpha-13 (PCDH-alpha-13)
Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.,similarity:Contains 6 cadherin domains.,
