Reactive species
Human;Mouse;Rat
Protein name
Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
I23O1 Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011],
Function
cytokine production, regulation of cytokine production, negative regulation of cytokine production, positive regulation of cytokine production, response to molecule of bacterial origin, acute inflammatory response, production of molecular mediator of acute inflammatory response, cytokine production during acute inflammatory response, regulation of tolerance induction, positive regulation of tolerance induction, regulation of T cell tolerance induction, positive regulation of T cell tolerance induction, regulation of chronic inflammatory response, positive regulation of chronic inflammatory response, negative regulation of immune system process, positive regulation of immune system process,regulation of leukocyte activation, negative regulation of leukocyte activation, regulation of adaptive immune response, positive regulation of adaptive immune response, regulation of adaptive immune re
