Reactive species
Human;Mouse
Gene Name
SEPT4 ARTS PNUTL2 SEP4 hucep-7
Protein name
Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SEPT4 Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Background
septin 4(SEPT4) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010],
Function
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subcellular location:Only observed in tumor tissue cells.,subunit:May assemble into a multicomponent structure.,tissue specificity:Expressed ubiquitously in adult and fetal tissues with particularly high expression in adult heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancer and malignant melanoma samples.,
