Reactive species
Human;Rat;Mouse;
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 50-190 of
human RELN (NP_005036.2).
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Other name
RL; ETL7; LIS2; PRO1598; RELN
Background
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell
interactions critical for cell positioning and neuronal migration during brain development.
This protein may be involved in schizophrenia, autism, bipolar disorder, major depression
and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are
associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript
variants encoding distinct isoforms have been identified for this gene. Other transcript
variants have been described but their full length nature has not been determined.
