Reactive species
Human;Rat;Mouse;
Protein name
Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ICAM5 Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008],
Function
function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 9 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.,
