Reactive species
Human;Rat;Mouse;
Protein name
Cation channel sperm-associated protein 1 (CatSper1) (hCatSper)
Dalton（DA）
human:85kD, Mouse 65-70kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CTSR1 Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed meiotically and poszt-meiotically.,function:Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.,induction:Down-regulated in patients lacking sperm motility.,similarity:Belongs to the cation channel sperm-associated family.,subunit:Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of a complex, at least composed of CATSPER1, HSPA1B and CATSPERB. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.,tissue specificity:Testis-specific. Specifically present in the principal piece of spe
