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Product code: YP-mAb-05393
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Product introduction

Reactive species
Human;Rat;Mouse;
Applications
WB
Antibody type
单克隆抗体
Gene Name
CAMLG CAML
Protein name
Calcium signal-modulating cyclophilin ligand (CAML)
Dalton(DA)
32kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CAMLG Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Stockpile
-20°C/1 year
Other name
Background
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008],
Function
function:Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.,subunit:The N-terminal domain binds to TNFRSF13B/TACI.,tissue specificity:Ubiquitous. Highest levels in brain, testis and ovary.,

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