Reactive species
Human;Rat;Mouse;
Protein name
E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-)
Immunogen
Synthesized peptide derived from human protein . at AA range: 470-550
Specificity
RNF6 Monoclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008],
Function
similarity:Contains 1 RING-type zinc finger.,tissue specificity:Weakly expressed in peripheral blood, spleen, prostate, testis and ovary.,
