Reactive species
Human;Mouse
Protein name
Dickkopf-related protein 3
Immunogen
The antiserum was produced against synthesized peptide derived from human DKK3. AA range:111-160
Specificity
Dkk-3 Monoclonal Antibody detects endogenous levels of Dkk-3 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
Western Blot: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
DKK3; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3
Background
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Function
function:Inhibitor of Wnt signaling pathway .,PTM:N-glycosylated.,similarity:Belongs to the dickkopf family.,tissue specificity:Highest expression in heart, brain, and spinal cord.,
