Reactive species
Human;Rat;Mouse;
Protein name
Cdc42 effector protein 4
Immunogen
The antiserum was produced against synthesized peptide derived from human BORG4. AA range:201-250
Specificity
Cdc42EP4 Monoclonal Antibody detects endogenous levels of Cdc42EP4 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CDC42EP4; BORG4; CEP4; Cdc42 effector protein 4; Binder of Rho GTPases 4
Background
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008],
Function
function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with CDC42 and RHOQ, in a GTP-dependent manner.,tissue specificity:Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.,
