Background
The WNT gene family consists of structurally related genes which encode secreted signaling
proteins. These proteins have been implicated in oncogenesis and in several developmental
processes, including regulation of cell fate and patterning during embryogenesis. This gene
encodes a member of the WNT family that signals through both the canonical and noncanonical WNT pathways. This protein is a ligand for the seven transmembrane receptor
frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in
regulating developmental pathways during embryogenesis. This protein may also play a role
in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow
syndrome. Alternate splicing results in multiple transcript variants
