Reactive species
Human;Rat;Mouse;
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin G. AA range:67-116
Specificity
Cathepsin G Monoclonal Antibody detects endogenous levels of Cathepsin G protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
Western Blot: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CTSG; Cathepsin G; CG
Background
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014],
Function
catalytic activity:Specificity similar to chymotrypsin C.,enzyme regulation:Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota.,function:Serine protease with trypsin- and chymotrypsin-like specificity. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
