Reactive species
Human;Rat;Mouse;
Immunogen
The antiserum was produced against synthesized peptide derived from human CAPN12. AA range:221-270
Specificity
Calpain 12 Monoclonal Antibody detects endogenous levels of Calpain 12 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
Western Blot: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CAPN12; Calpain-12; Calcium-activated neutral proteinase 12; CANP 12
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012],
Function
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 1 EF-hand domain.,
