Reactive species
Human;Mouse;Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 86-108 of
human CYP7A1 (P22680
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at 4℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.1% sodium azide and 0.1% gelatin.
Other name
CP7A; CYP7; CYPVII; CYP7A1
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The
cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in
drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic
reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway
in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step
and the major site of regulation of bile acid synthesis, which is the primary mechanism for
the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are
associated with defects in bile acid synthesis.
