Reactive species
Human;Rat;Mouse
Gene Name
NFAT5 KIAA0827 TONEBP
Immunogen
Synthetic peptide from human protein at AA range: 212-284
Specificity
The antibody detects endogenous NFAT5
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
Nuclear factor of activated T-cells 5 (NF-AT5;T-cell transcription factor NFAT5;Tonicity-responsive enhancer-binding protein;TonE-binding protein;TonEBP)
Background
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,function:Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Does not bind with Fos and Jun transcription factors. But might be caMABle of forming stable dimers with DNA elements.,tissue specificity:Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.,
