Reactive species
Human;Rat;Mouse;
Protein name
MDS1 and EVI1 complex locus protein MDS1
Immunogen
The antiserum was produced against synthesized peptide derived from human MECOM. AA range:1-50
Specificity
PRDM3 Monoclonal Antibody detects endogenous levels of PRDM3 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
MECOM; MDS1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1
Background
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],
Function
disease:A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.,disease:A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.,miscellaneous:Can be produced either as a separate transcript and as a normal fusion transcript with EVI1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:May interact with CTBP1.,
