Reactive species
Human;Mouse;Rat
Protein name
CDK5 regulatory subunit-associated protein 3
Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5RAP3. AA range:341-390
Specificity
HSF-27 Monoclonal Antibody detects endogenous levels of HSF-27 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CDK5RAP3; IC53; MSTP016; OK/SW-cl.114; PP1553; CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; Protein HSF-27
Background
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013],
Function
function:Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1.,PTM:Phosphorylated in vitro by CDK5.,similarity:Belongs to the CDK5RAP3 family.,subunit:Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein.,tissue specificity:Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.,
