Background
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of
the Gli family. They are characterized as DNA-binding transcription factors and are
mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in
the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also
thought to play a role during embryogenesis. Mutations in this gene have been associated
with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall
syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
