Reactive species
Human;Mouse
Protein name
Death-inducer obliterator 1
Immunogen
The antiserum was produced against synthesized peptide derived from human DIDO1. AA range:161-210
Specificity
Dio-1 Monoclonal Antibody detects endogenous levels of Dio-1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse,IgG
Dilution rate
WB: 1/500 - 1/2000
Purification process
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
DIDO1; C20orf158; DATF1; KIAA0333; Death-inducer obliterator 1; DIO-1; hDido1; Death-associated transcription factor 1; DATF-1
Background
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008],
Function
disease:Defects in DIDO1 may be a cause of myeloid neoplasms.,function:Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 TFIIS central domain.,subcellular location:Translocates to the nucleus after pro-apoptotic stimuli.,tissue specificity:Ubiquitous.,
