Reactive species
Human,Mouse,Rat
Gene Name
HSD17B3 EDH17B3
Protein name
Testosterone 17-beta-dehydrogenase 3 (17-beta-hydroxysteroid dehydrogenase type 3) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase)
Immunogen
Synthesized peptide derived from human HSD17B3
Specificity
This antibody detects endogenous levels of HSD17B3 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids . Favors the reduction of androstenedione to testosterone . Testosterone is the key androgen driving male development and function . Uses NADPH while the two other EDH17B enzymes use NADH . Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 . Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms .
