Reactive species
Human,Mouse
Protein name
Ankyrin-3 (ANK-3) (Ankyrin-G)
Immunogen
Synthesized peptide derived from human ANK3
Specificity
This antibody detects endogenous levels of ANK3 at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption . ; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
