Reactive species
Human,Mouse,Rat
Gene Name
RCN3 UNQ239/PRO272
Protein name
Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
Immunogen
Synthesized peptide derived from human Reticulocalbin 3
Specificity
This antibody detects endogenous levels of Reticulocalbin 3 at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum . Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens . This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion .
