Reactive species
Human,Mouse,Rat
Protein name
Sideroflexin-1 (Tricarboxylate carrier protein) (TCC)
Specificity
This antibody detects endogenous levels of SFXN1 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway . Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors . Transports both D-serine and L-serine . Also able to transport other amino-acids, such as alanine . May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).
