Reactive species
Human,Mouse
Gene Name
CBLL1 HAKAI RNF188
Protein name
E3 ubiquitin-protein ligase Hakai (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (RING finger protein 188) (c-Cbl-like protein 1)
Immunogen
Synthesized peptide derived from human CBLL1
Specificity
This antibody detects endogenous levels of CBLL1 at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Its function in the WMM complex is unknown .
