Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46)
Immunogen
Synthesized peptide derived from human PDE4A AA range:530-580
Specificity
This antibody detects endogenous levels of PDE4A at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. ; [Isoform 1]: Efficiently hydrolyzes cAMP. ; [Isoform 2]: Efficiently hydrolyzes cAMP. ; [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. ; [Isoform 4]: Efficiently hydrolyzes cAMP. ; [Isoform 6]: Efficiently hydrolyzes cAMP. ; [Isoform 7]: Efficiently hydrolyzes cAMP.
