Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17)
Immunogen
Synthesized peptide derived from human PDE8A
Specificity
This antibody detects endogenous levels of PDE8A at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development . Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling . Protects against cell death induced by hydrogen peroxide and staurosporine .
