Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II)
Immunogen
Synthesized peptide derived from human IMPDH2
Specificity
This antibody detects endogenous levels of IMPDH2 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth . Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism . It may also have a role in the development of malignancy and the growth progression of some tumors.
