Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
VTCN1 B7H4 UNQ659/PRO1291
Protein name
V-set domain-containing T-cell activation inhibitor 1 (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
Immunogen
Synthesized peptide derived from human VTCN1
Specificity
This antibody detects endogenous levels of VTCN1 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Subcellular Location：
Cell membrane ; Single-pass type I membrane protein . Expressed at the cell surface. A soluble form has also been detected. .
