Home / Products / Monoclonal antibody /

Estrogen Receptor α (ABT4R) rabbit mAb

Product navigation

Estrogen Receptor α (ABT4R) rabbit mAb

Citation (0) Contact

Product code: YP-Ab-18056

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;

Applications

WB; IHC; ELISA

Antibody type

Monoclonal antibodies

Gene Name

Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

Protein name

Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

Dalton（DA）

66kD

Immunogen

Synthesized peptide derived from human Estrogen Receptor α. AA range:450-595

Specificity

This antibody detects endogenous levels of ESR1

Constitute

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source

Monoclonal, Rabbit IgG1, Kappa

Dilution rate

IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

Purification process

Recombinant Expression and Affinity purified

Concentration

mg/ml

Stockpile

-15°C to -25°C/1 year(Do not lower than -25°C)

Other name

ESR1 ESR NR3A1

Background

estrogen receptor 1(ESR1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014],

Function

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter

Open

Product Details

Customer data and reviews (0)

Fold content

Citation

Fold content

Background information

FAQ

Fold content

Experimental scheme

Fold content

IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Estrogen Receptor α (ABT4R) rabbit mAb

Product navigation

Estrogen Receptor α (ABT4R) rabbit mAb

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

Antibody customization service

ELISA service

Protein service

Biochemical testing services

Literature search

Antibody application technology resources

ELISA application technology resources

Research strategies and research tools

Product literature citation

About Us

Recruit

News

Contact

Technical FAQ