Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
DIO1 ITDI1 TXDI1
Protein name
Type I iodothyronine deiodinase (EC 1.97.1.10) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)
Immunogen
Synthesized peptide derived from human DIO1
Specificity
This antibody detects endogenous levels of DIO1 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
