Reactive species
Human,Rat
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW: 131 kDa; Observed MW: 160 kDa
Immunogen
Purified recombinant human HDAC6 protein expressed in E.coli.
Dilution rate
WB: 1/500-1/1000
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Background
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
