Applications
ICC/IF,FC,ELISA
Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant fragment of human CD62E expressed in E. Coli.
Dilution rate
IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
ELAM; ESEL; SELE; ELAM1; LECAM2
Background
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
