Reactive species
Human,Mouse
Antibody type
Polyclonal Antibody
Dalton（DA）
Calculated MW: 54 kDa; Observed MW: 54 kDa
Immunogen
A synthesized peptide derived from human MLKL
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma
membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane
damage. Does not have protein kinase activity.
