Reactive species
Human,Mouse,Rat
Antibody type
Polyclonal Antibody
Dalton（DA）
Calculated MW: 18 kDa; Observed MW: 18 kDa
Immunogen
Fusion protein of human RNASE1
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
RAC1; RIB1; RNS1
Background
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
