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PI3 Kinase p110 alpha Rabbit mAb

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Product code: YP-Ab-17844
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Product introduction

Reactive species
Human,Mouse,Rat
Applications
WB,ICC/IF,IP
Antibody type
Monoclonal antibodies
Gene Name
PIK3CA
Protein name
Dalton（DA）
Calculated MW: 124 kDa; Observed MW: 110 kDa
Immunogen
synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha
Specificity
Constitute
Source
Dilution rate
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Purification process
Concentration
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PtdIns-3-kinase p110
Background
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.
Function

Open

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