Reactive species
Human,Mouse,Rat
Applications
WB,IHC-P,ICC/IF,IP,FC
Antibody type
Polyclonal Antibody
Dalton（DA）
Calculated MW: 71 kDa; Observed MW: 55 kDa
Immunogen
A synthesized peptide derived from human TXNRD1
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles
Other name
TR; TR1; TXNR; TRXR1; GRIM-12
Background
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
