Reactive species
Human,Mouse
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW: 36 kDa;Observed MW:39kDa Clonality
Immunogen
synthesized peptide derived from human Phospho-IKB alpha (S36)
Dilution rate
WB: 1/500-1/1000 FC: 1/50
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
I kappa B alpha; IkappaBalpha; IkB-alpha; IKBA; IKBalpha; MAD3; NF kappa B inhibitor alpha; NFKBI; NFKBIA;
Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
