Reactive species
Human,Mouse,Rat
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
Immunogen
Recombinant protein of mouse Caspase-11
Dilution rate
WB: 1/500-1/1000 IP: 1/20
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
Caspl; ich-3; CASP-4; Casp11; CASP-11
Background
Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.
