Reactive species
Human,Mouse
Applications
WB,IHC-P,ELISA
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW: 125 kDa
Immunogen
Purified recombinant fragment of human CD163 expressed in E. Coli.
Dilution rate
WB: 1/500-1/1000 IHC: 1/100-1/200 ELISA: 1/10000
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
M130; MM130; SCARI1
Background
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
