Antibody type
Monoclonal antibodies
Immunogen
synthesized peptide derived from Human CD32
Dilution rate
FC: 5μL per test for million cells or whole blood in 100 μL volume.
Stockpile
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.
Other name
Fc fragment of IgG; low affinity IIb; receptor (CD32); CD32; FCG2; CD32B; FCGR2; IGFR2
Background
CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).
