Reactive species
Human,Mouse,Rat
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW:33kDa;Observed MW:46kDa
Immunogen
synthesized peptide derived from human PD-L1 (CD274)
Dilution rate
WB: 1/500-1/1000 IHC: 1/100-1/200
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; CD274;
Background
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens.
