Reactive species
Human,Mouse,Rat
Applications
WB,IHC-P,ICC/IF,IP,FC
Antibody type
Monoclonal antibodies
Dalton（DA）
Calculated MW: 28 kDa; Observed MW: 28 kDa
Immunogen
synthesized peptide derived from human Caspase-14
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50 FC: 1/50-1/100
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Other name
CASP14; Caspase-14; Caspase 14; MICE; CASP-14
Background
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8. May also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
