Antibody type
Polyclonal Antibody
Protein name
Schlafen family member 11
Immunogen
Synthesized peptide derived from human SLFN11
Specificity
This antibody detects endogenous levels of SLFN11 at Human
Constitute
Liquid in PBS containing 50% glycerol, and 0.2387% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Stockpile
‘-15°C to -25°C/1 year(Do not lower than -25°C)
Background
Nucleus . Chromosome . Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).
Function
Inhibitor of DNA replication that promotes cell death in response to DNA damage . Acts as a guardian of the genome by killing cells with defective replication . Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death . Acts independently of ATR . Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis . Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner . Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides . The exact inhibition mechanism i
