Reactive species
Human, Mouse,Rat
Antibody type
Monoclonal antibodies
Protein name
Interleukin-1 beta (IL-1 beta) (Catabolin)
Immunogen
Synthesized peptide derived from human IL-1β
Specificity
This antibody detects endogenous levels of IL-1β at Human, Mouse,Rat
Constitute
PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
Source
Mouse,monoclonal:IgG1,kappa
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
Protein G
Other name
Interleukin-1 beta (IL-1 beta) (Catabolin)
Background
interleukin 1 beta(IL1B) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008],
Function
domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Mono
