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MET (Phospho Tyr1365) Rabbit pAb

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MET (Phospho Tyr1365) Rabbit pAb

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Product code: YP-Ab-17307

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human, Mouse,Rat

Applications

IHC,WB

Antibody type

Polyclonal Antibody

Gene Name

MET

Protein name

Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

Dalton（DA）

155kD

Immunogen

Synthesized peptide derived from human MET (Phospho Tyr1365)

Specificity

This antibody detects endogenous levels of MET (Phospho Tyr1365) Rabbit pAb at Human, Mouse,Rat

Constitute

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source

Rabbit,polyclonal

Dilution rate

WB 1:500-2000 IHC 1:50-200

Purification process

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

Background

MET proto-oncogene, receptor tyrosine kinase(MET) Homo sapiens This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],

Function

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.,disease:Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].,disease:Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.,disease:Defects in MET may be associated with gastric cancer.,disease:Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in l

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

MET (Phospho Tyr1365) Rabbit pAb

Product navigation

MET (Phospho Tyr1365) Rabbit pAb

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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