Reactive species
Human, Mouse,Rat
Antibody type
Monoclonal antibodies
Protein name
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Immunogen
Synthesized peptide derived from human HMGB1
Specificity
This antibody detects endogenous levels of HMGB1 at Human, Mouse,Rat
Constitute
PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
Source
Mouse,monoclonal:IgG1, Kappa
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
Protein G
Other name
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Background
high mobility group box 1(HMGB1) Homo sapiens This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015],
Function
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,
