Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
PDZ and LIM domain protein 5
Immunogen
The antiserum was produced against synthesized peptide derived from human PDLIM5. AA range:208-257
Specificity
PDLIM5 Polyclonal Antibody detects endogenous levels of PDLIM5 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PDLIM5; ENH; L9; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
Background
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:May play a role in genetic susceptibility to schizophrenia. PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.,function:May play an important role in the heart development by scaffolding PKC to the Z-disk region.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 3 LIM zinc-binding domains.,subunit:Interacts with various PKC isoforms through the LIM domains. Interacts with actin and alpha-actinin through the PDZ domain.,tissue specificity:Heart and skeletal muscle specific.,
