Reactive species
Human;Monkey
Antibody type
Polyclonal Antibody
Protein name
Integrin alpha-7
Immunogen
The antiserum was produced against synthesized peptide derived from human ITGA7. AA range:940-989
Specificity
Cleaved-Integrin α7 LC (E959) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α7 LC protein resulting from cleavage adjacent to E959.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
ITGA7; Integrin alpha-7
Background
integrin subunit alpha 7(ITGA7) Homo sapiens The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009],
Function
alternative products:Additional isoforms seem to exist. There is a combination of at least five alternatively spliced domains, three extracellular (X1, X2 and D) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) does not appear to be expressed. In vitro generated isoform X2C shows function. So far detected are isoform Alpha-7X1A, isoform Alpha-7X2B (major), isoform Alpha-7X2DB (minor) and minor isoforms containing segment X1X2. Experimental confirmation may be lacking for some isoforms,developmental stage:In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation.,disease:Defects in ITGA7 are associated with a form of congenital myopathy; a group of heterogeneous muscle disorders which are thought to result from abnormal muscle development. Muscle weakness is either no
