Reactive species
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Potassium voltage-gated channel subfamily D member 2
Immunogen
The antiserum was produced against synthesized peptide derived from human Kv4.2/KCND2. AA range:581-630
Specificity
Kv4.2 Polyclonal Antibody detects endogenous levels of Kv4.2 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
KCND2; KIAA1044; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as i
Function
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the potassium channel family. D (Shal) subfamily.,subcellular location:Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.,subunit:Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNI
