Home / Products / Polyclonal antibody /

KIR3.1 Polyclonal Antibody

Product navigation

KIR3.1 Polyclonal Antibody

Citation (0) Contact

Product code: YP-Ab-16443

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Mouse;Rat

Applications

WB;IHC

Antibody type

Polyclonal Antibody

Gene Name

KCNJ3

Protein name

G protein-activated inward rectifier potassium channel 1

Dalton（DA）

56kD

Immunogen

The antiserum was produced against synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3. AA range:151-200

Specificity

KIR3.1 Polyclonal Antibody detects endogenous levels of KIR3.1 protein.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Polyclonal, Rabbit,IgG

Dilution rate

WB 1:500-2000;IHC-p 1:50-300

Purification process

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at

Function

function:This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.,

Open

Product Details

Customer data and reviews (0)

Fold content

Citation

Fold content

Background information

FAQ

Fold content

Experimental scheme

Fold content

IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

KIR3.1 Polyclonal Antibody

Product navigation

KIR3.1 Polyclonal Antibody

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

Antibody customization service

ELISA service

Protein service

Biochemical testing services

Literature search

Antibody application technology resources

ELISA application technology resources

Research strategies and research tools

Product literature citation

About Us

Recruit

News

Contact

Technical FAQ